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Hydrocodone/acetaminophen is a combination prescription medicine containing two active ingredients:

ComponentRoleHydrocodone bitartrateOpioid analgesicAcetaminophenNon-opioid analgesic and fever reducer10/325 mg10 mg hydrocodone + 325 mg acetaminophen per tablet

Current U.S. drug labeling identifies hydrocodone bitartrate/acetaminophen 10 mg/325 mg as an oral prescription tablet and a Schedule II controlled substance.

Hydrocodone works primarily through opioid receptors in the central nervous system to reduce the perception of pain. Acetaminophen contributes additional analgesic activity through different mechanisms. Together, the ingredients can provide pain relief when prescribed and monitored appropriately.

Common brand names historically associated with hydrocodone/acetaminophen include Vicodin, Norco, and Lortab, although brand availability and formulations can vary. Generic hydrocodone/acetaminophen products are also available.