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What Is Tapentadol?

Tapentadol is the active ingredient in the FDA-approved prescription drugs Nucynta and Nucynta ER. It is a strong opioid pain medicine used to manage short-term (acute) pain in adults when other pain treatments are not effective enough .

The FDA requires tapentadol products to carry a boxed warning—the strongest safety warning—alerting to risks of addiction, life-threatening respiratory depression, and fatal interactions with alcohol or other central nervous system depressants .