machroS^â is a revolutionary single-use chromatography platform that enables direct capture from crude, unclarified materials. Eliminate the Clarification Train machroS^â eliminates the need for primary and secondary clarification steps, allowing direct purification from high-density, low-viability cultures (>30000 NTU) or whole blood. Simplified Process Flow: Mix crude, unclarified material with machroS media. System captures target bound to machroS media and discards unbound material. Wash and Elute product. Dramatic Cost & Time Reduction 81% cost reduction per gram of mAb. 76% cost reduction per batch. Saves 42 hours of total time per batch.