10 revolutionary biotech startups changing the world as we know it

February 23, 2021

Top 10 biotech startups

The biotech industry is one of the most ambitious, innovative and fast-growing fields. Biotech startups have a mission to save lives and improve our everyday life. Thankfully, there are so many cutting-edge biotech startups doing amazing things for the world. As part of this article we will highlight some of the most promising biotech startups along with their missions.

What are biotech startups?

First let’s understand more about biotechnology and what it is. In a nutshell, biotech seeks to understand and manipulate the basic building blocks of living things. Using molecular biology techniques, biotech companies study the genetic, chemical and physical properties of cells, tissues and organisms. This analysis is later used to identify any practical uses. 

Biotechnology uses cellular and biomolecular processes to create technologies and products that will improve our lives and health. As one of the most ambitious industries, biotech is very attractive to aspiring entrepreneurs who want to make a huge impact on the world. 

However, biotech startups also face high risks which are also expensive. Nevertheless, new startups quite often receive multimillion-dollar investments and media attention, which allows them to move forward and discover new technologies that can bring huge changes to the world.

Top 10 biotech startups worldwide

We were mind-blown by the revolutionary innovations these biotech startups have come up with so we have created the following list of the industry’s avant-garde.

1. Samumed – Tissue regeneration

Samumed is quickly becoming one of the richest biotech startups thanks to their focus on stem cells. Their mission is unbelievably inspiring as they seek to learn how to manipulate stem cells in order to prevent bone and joint diseases, skin diseases and even hair loss! Wow, simply an incredible mission. 

Essentially, this biotech startup is trying to find a way to force cells of aging people to regenerate as quickly as the growing embryos do. The studies that have been done to date have promising results showing that the drugs they have developed really help stimulate hair growth, reduce pain and improve joint mobility. However, since this startup and their developments are still in very early stages, we cannot expect to see their drugs make it to market anytime soon.

2. Ginkgo Bioworks – Cellular biology

This trailblazing biotech startup firmly believes that from bacteria we can produce anything. Their research focuses on modifying microorganisms and it works with several partner companies to develop microbes for various different uses. 

Ginkgo Bioworks even partnered with Bayer to create microbes for agricultural needs. One very unique and fascinating project of this biotech is to recreate the aroma of long-extinct plants. For this they collaborate with Harvard University where they get samples of tissues of some extinct plants. 

This endeavor proved successful as the startup presented some of their recreated fragrances at a recent conference in Boston. They achieved this by supplementing the missing fragments with DNA of living related species, which enabled the genes for production of essential oils to be reintroduced into the yeast genome.

3. Beam Therapeutics – Genetic medicine

Based in Cambridge, MA, they focus on enabling the editing of the human genome. It aims to commercialise the CRISPR system of DNA sequences.

CRISPR technology works in the following principle: 

  • DNA is cut with molecular scissors
  • Specialists restore the created gap with a system called non-homologous end joining
  • Simultaneously genetic information is changed at the spot of incision
  • Mutation resultantly occurs in a pre-selected DNA region

Moreover, Beam Therapeutics even created a base editor through which you can change individual “letters” of the genetic code without cutting. This method compared to the “scissors” method of CRISPR acts as a molecular pencil. The potential for this solution is huge and it is expected to make a boom in the biotech industry in the near future.

4. Auris Health – Robotic medical devices

Auris Health is a biotech startup which focuses on manufacturing surgical robots. These surgical robots are being developed with the goal to enable minimally invasive treatments with high precision. Some of their main use cases are treatment of cancer cells in order to halt the progression of the disease. Thus, by using their technology, surgeons will be able to control surgeries through a video display whilst the cancer surgery is conducted mostly by robots. 

They have partnered with Johnson & Johnson to push the boundaries of medical robotics even further. Having the resources of one of the largest pharmaceuticals at their disposal seriously puts this startup in a favourable advantageous position.

5. Cerevel – Neuroscience diseases

Cerevel is the biotech startup that is highly focused on finding and providing innovative treatments to life-threatening neuroscience diseases that currently affect millions of people worldwide. 

This groundbreaking startup combines their thorough understanding of biology and neurocircuitry of the brain with advanced chemistry and central nervous system receptor pharmacology to discover and create new treatments. 

Their ambitious goal is to help millions of people that suffer from Parkinson’s disease, epilepsy and schizophrenia through their novel therapies. And with their highly experienced team of leaders along with the strong support from Pfizer and Bain Capital, we believe this biotech startup is just getting started. The milestones they have the possibility to achieve are many and admirable at that. 

6. Century Therapeutics – Cell therapies

This biotech startup is frivolously aiming to develop novel allogeneic living drugs that will overcome the limitations of first-generation cell therapies. Their science is quite impressive as they are seeking to create genetically engineered immune effector cell therapies. These therapies are derived from induced pluripotent stem cells coming from healthy adults, and are specifically engineered to target hematologic and solid cancers as well as overcome barriers confronting autologous cell therapies.

Century Therapeutics are extremely focused in their mission to develop effective stem cell therapies which may help humanity fight cancers more effectively.

7. Passage Bio – Genetic medicines

Ambitiously focused on innovating within the field of genetic medicines, they seek to develop transformative therapies for the treatment of rate monogenic central nervous system disorders.

Passage Bio is a biotech startup with a clear mission to develop a portfolio of five life-transforming AAV-delivered therapeutics. Their focus is set on unique aspects and therapy goals for a given indication and screens a variety of AAVs in non-human primates to choose the optimal capsid and route of delivery to best meet the clinical needs of the patients.

8. Maze – Genetic navigator

Maze is the biotech startup that focuses on decoding the mysteries of genetic modifiers in a range of severe diseases. They use the advances in human genetics and functional genomics to systematically identify genetic modifiers and turn these insights into medicines. To achieve their mission, they have teamed up with some of the brightest and the best scientific pioneers and industry leaders.

As genetic navigators, Maze are paving the way to decode the complex maze of human genetics in an effort to fight diseases. Their ultimate goal is to develop medicines that will transform the lives of people with serious illnesses.

9. Ribon – Stress support pathway

This biotech startup is pursuing the creation of novel small molecules that target cancer through its dependency on stress support pathways. They have even created their own platform BEACON to facilitate this. They use their platform to find and explore the vulnerabilities of cancer cells to cellular stress.

Being a clinical stage biotech startup, Ribon is working in the emerging field of stress support pathway biology, focusing on a set of enzymes such as PARP7 that utilize nicotinamide adenine dinucleotides (NAD). NAD regulates functions like DNA replication and gene transcription in moments of cellular stress. Ribon firmly states that this link is an exceptional area for developing cancer drugs, due to the fact that cancer cells have high levels of cellular stress. Thus modulating the human immune system can contribute to the development of antitumor activity.

10. 10x Genomics – Gene sequencing

Creating an impressive platform with the goal to help researchers better identify subtle variations in DNA is what this biotech startup is doing. 

10x Genomics has essentially created an advanced DNA sequencing technology which identifies variations in biological samples and shreds them into miniature fragments before sequencing. They later use computers to assemble them into a genome. The goal of this company is to create the world’s most advanced gene sequencing technology to be used in all kinds of scientific research. Their transformative technological advancements are enabling new discoveries in diseases as well as uncovering new unrecognizable cell types.

What all these biotech startups have in common

All these revolutionary biotech startups have shown us that armed with knowledge and dedication we can accomplish any mission. We are extremely excited to see how their progress develops as well as keeping an eye on new upcoming breakthroughs. Hopefully, these companies can inspire more innovations within the biotech industry and push the boundaries of this science. 

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